《多肽、化学、生物和药物科学》内容简介：The 11th Chinese International Peptide Symposium (CPS-2010), hosted by Lanzhou University, was held in Lanzhou, China, July 5-8, 2010. More than 300 participants, from 12 countries and districts as well as represents from 30 or so related companies attended this symposium. Thus, it was gratifying to see that this meeting retained both its international flavor and participants loyalty at a time when there are a great many symposia held each year on similar subjects. The goal of this symposium was to provide a forum for exchange of ideas, review of the progress in the field of peptide research, encourage the cooperation between the international and Chinese scientific communities. We believe that this goal had been achieved.
The scientific program, thanks to the insights and efforts of the program committee, was extraordinary rich, diverse and exciting. It was comprised of 14 sessions with 22 plenary lectures, 37 invited lectures and 116 poster presentations, concerning bioactive peptides, peptide immunology, structure and conformation of peptides and proteins, molecular diversity and peptide libraries, synthetic methods, de novo design and synthesis of proteins and peptides, ligand-receptor interactions, the chemistry-biology-interface, self-assembling peptides and challenging problems in peptides. 

Preface Ⅴ
The Eleventh Chinese Peptide Symposium (CPS-2010) Ⅶ
Acknowledgments Ⅹ
Cathay Award Ⅺ
Xiaoyu Hu Memorial Award Ⅻ
Chinese Peptide Symposium ⅩⅢ
Abbreviations ⅩⅣ
Session 1 Design of Peptides and Mimetics 1
Biomimetic Nanostructures Based on Enforced Folding and Assembly 3
Bing Gong

Agonist vs. Antagonist Behavior of Opioid Peptides Containing Novel
Tyrosine or Phenylalanine Analogues in Place of Tyr1 13
Grazyna Weltrowska, Irena Berezowska, Brian C. Wilkes, Carole Lemieux, Nga N. Chung, Jinguo Ding, Yixin Lu, Peter W. Schiller,

Novel Non-Peptide Ghrelin Receptor Ligands Based on
3,4,5-Trisubstituted 1,2,4-Triazoles 20
Jean-Alain Fehrentz, Anne-Laure Blayo, Mathieu Bibian, Aline Moulin, Luc Demange, Damien Boeglin, Céline M'Kadmi, Jean-Claude Galleyrand, Didier Gagne, Vittorio Locatelli, Antonello Torsello, Daniel Perrissoud, Jean Martinez,

Synthesis and Structure-Activity Relationship of Marinostatin,
An Ester-Linked Serine Protease Inhibitor 25 Misako Taichi, Toshimasa Yamazaki, Tadashi Teshima, Yuji Nishiuchi

Mitocryptides: A Novel Family of Neutrophil-Activating Peptides Derived
from Mitochondrial Proteins and Their Regulatory Mechanisms 30 Hidehito Mukai, Tetsuo Seki, Akiyoshi Fukamizu, Yoshiaki Kiso

Novel Opioid Peptide Derived Antagonists Containing 3-(2,6- Dimethyl-4-Carbamoylphenyl)-Propanoic Acid (Dcp) in Place of Tyr1 33
Peter W. Schiller, Grazyna Weltrowska, Thi M.-D. Nguyen, Carole Lemieux, Nga N. Chung, Tze Keong Lum, Yoon Wui Leow Augustine, Yixin Lu
Design, Synthesis and Evaluation of Antitumor Activity against Human Cancer Cell Lines, Sansalvamide Analogues 39
Xiaoli Zhen, Yihua Yang, Junzhang Li, Xia Tian, Hua Zhang, Shouxin Liu

Session 2 Peptide Synthesis and Preparation 41
Regioselective Disulfide Bond Formation during SPS of Human Relaxin-3: Evaluation of An Alternative Method for Removal of the S-Acm Groups via Reaction with Silver Triflate and Subsequent Mild Aqueous DMSO Oxidation 43
Feng Lin, John D. Wade

Synthetic Studies of Membrane Proteins: Subunit C of Human F1Fo-ATP Synthase and Voltage Sensor Only Protein (78-222) 47
Saburo Aimoto, Ken'ichiro Nakamura, Takeshi Sato, Toru Kawakami, Toshiaki Hara

One-Pot Synthesis of Rigid Cyclic N-Methyl-γ-Peptides 54
Zhongzhu Chen, Liangchun Li, Menglan Lv, Jin Zhu and Jingen Deng

Tbfmoc Methioine: Its Synthesis and Application for the Solid Phase
Synthesis of Ubiquitin Analogues and Product Purification 58 Naifeng Hu, Zhi Jin, Pu Wang

Intein-Mediated Biosynthesis of Bracelet Cyclotide 63
Xinya Hemu, Lin Cai, Clarence T. T. Wong, James P. Tam

Convergent and Atom-Economic Synthesis of Phosphinopeptides 67
Fanhua Meng, Jiaxi Xu

One-Step Oxidative Folding of A Novel Cystine-Knot Cyclotide Under Denaturation Conditions 69
Clarence T. T. Wong, Misako Taichi, Hideki Nishio, Yuji Nishiuchi, James P. Tam

Synthesis of Angiotensin I-Converting Enzyme Inhibitory Peptides and Their Self-Assembling Microstructure Characterization 72
Dawei Li, Yan Ding, Gang Cao, Ruijie Zhang, Jin Ren, Chuanguang Qin

Fast Automated Synthesis of An Antimicrobial Peptide Analog Using UV-Monitoring on the Tribute? 77
German E. Fuentes, Christina A. Chantell, Hirendra Patel, Mahendra Menakuru

Synthesis of Cyclic Peptides by Alknye-Azide Click Chemistry Cyclization 81
Liangyou Wang, Dongdong Lu, Mingxing Lu
Thioester Preparation through O-S Acyl Shift under Acidic Condition 83
Khee Dong Eom, Young Soon Shin, James P. Tam

A Novel Strategy for Total Solid-Phase Synthesis of Kahalalide A Derivatives 86
Tingting Wei, Jin Ren, Xiaoya Shang, Gang Cao, Chuanguang Qin

Session 3 Methodologies in Peptide Research 91
Session 4 Peptide Therapeutics and Application 135
Session 5 Bioactive Peptides and Pharmacology 197
Author Index 257
Subject Index 260